Animal DNA Testing

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Centronuclear Myopathy (CNM) Disease Test for Labrador Retrievers

Centronuclear Myopathy (CNM) is an inherited autosomal recessive disorder. Affected pups start with significant weight less at just a few weeks of age. Within a few months, there is a loss of tendon reflexes, awkward gait and exercise intolerance.

DDC Veterinary is offering DNA Testing for Centronuclear Myopathy. Labrador Breeders have an accurate, convenient, and affordable tool to help them avoid producing CNM affected offspring and significantly reduce the gene frequency in future generations.

There are 3 possible genotypes reported for Centronuclear Myopathy:

  • CLEAR (those having 2 copies of the normal allele and appear to be normal).
  • CARRIER (those having 1 copy of the normal allele and 1 copy of the mutation but appear to be normal).
  • AFFECTED (those having 2 copies of the mutation and will likely begin to show weight loss, muscle weakness and exercise intolerance after a few months of age.

It is important to note that although carriers will not show clinical signs for the disease, if used for breeding, they will pass on the mutation 50% of the time, therefore a carrier x carrier mating will likely result in producing affected pups in 25% of the offspring.

Highlights regarding this new test include:

  • DNA samples can be collected easily at home using buccal (cheek) swabs.
  • Dogs can be DNA tested at ANY age using the buccal swabs.
  • The cost for testing is $58 (US) per canine with a $10 discount per test for 5 or more samples submitted at the same time.
  • DNA results are emailed within 5 business days of receipt of the samples

Canine DNA frequently asked questions

For more information about how these test results can be used for registration, contact the Orthopedic Foundation for Animals (OFA) or the Canine Health Information Center (CHIC).

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